SSM-based Electrophysiology
Membrane transport proteins are important drug discovery targets because of their relevance to a broad range of indications, including cancer, neurological and metabolic disorders, cardiovascular, or inflammatory diseases. Establishing predictive and scalable assays to identify and characterize bioactive substances for members of this protein family has been challenging and often required the use of radioactive labels.
Nanion’s SURFE²R platform employs label-free, Solid-Supported Membrane (SSM)-based electrophysiology to resolve small currents of transporters and pumps in native or artificial membrane vesicles.
Backed by Nanion’s electrophysiology expertise and technical know-how, Assay.Works offers assay development, proof-of-principle studies, and compound screening on the SURFE²R 96SE as an economic, low-risk option for researchers seeking predictive assays for membrane transporters.
Targets
- Electrogenic membrane transporters like symporters, exchangers or uniporters
- Ion pumps
- Ligand-gated ion channels
SURFE2R 96SE
- Records 96 wells in parallel
- Online liquid handling
- Automated data analysis and export
- Up to 10,000 data points per day
Assay Samples
- Liposomes with reconstituted membrane proteins
- Membranes prepared from primary or engineered cells, or tissue extracts
